Oral and uro-vaginal intra-amniotic infection in women with preterm delivery: A case-control study

Autores: Montenegro DABorda LFNeuta YGómez LACastillo DMLoyo D, Lafaurie GI

 

Abstract

Aim:

The aim of the present study was to establish the association between the presence of oral and uro-vaginal microorganisms in the placental membrane and preterm delivery (PTD), the premature rupture of membranes (PRM), and the clinical signs of intra-amniotic infection.

Methods:

Eighty-four women with PTD and 127 women with delivery at term were assessed for the PRM, clinical signs of intra-amniotic infection, and the presence of periodontitis. Twenty-seven microorganisms were identified in the placental tissue using nested polymerase chain reaction (PCR). Porphyromonas gingivalis (P. gingivalis) was quantified by droplet digital PCR.

Results:

The prevalence of microorganisms was 9.47% (20/211). P. gingivalis was the most prevalent (12/211, 5.68%). Mycoplasma hominis, Ureaplasma urealyticum, Staphylococcus spp, and Fusobacterium nucleatum were isolated at a very low frequency in the placenta. Candida albicans was associated with PTD (P = 0.027). Periodontitis was associated with clinical signs of infection (odds ratio [OR] = 3.8, 95% confidence interval [CI]: 1.28-13.5) and with PTD (OR = 1.99; 95% CI: 1.07-3.72).

Conclusions:

The presence of P. gingivalis in the placenta was not associated with perinatal complications. Detecting microorganisms in the placenta by nested PCR is not relevant, as it has a poor association with clinical variables that establish the diagnosis of chorioamnionitis. However, periodontitis was associated with the clinical signs of intra-amniotic infection and PTD.

© 2019 John Wiley & Sons Australia, Ltd.

Fuente:

J Investig Clin Dent. 2019 May;10(2):e12396. doi: 10.1111/jicd.12396. Epub 2019 Jan 20.

PMID: 30663264 DOI: 10.1111/jicd.12396

Keywords:

Porphyromonas gingivalis ; chorioamnionitis; intra-amniotic infection; periodontitis; preterm delivery.

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